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-synuclein, and that is a principal element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) anxiety, recommend that dysfunction of the intracellular proteinase techniques, like ubiquitin-proteasome process or lysosomal process, which gets rid of unwanted tox

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